Presented by Helen Brown (University of Edinburgh)
This course will cover the statistical background to the mixed model and will emphasise its practical application in medical data with particular reference to clinical trials. All analyses will be illustrated using SAS and lectures will be combined with practical sessions in order to reinforce concepts. The course will be based on material from the textbook Applied Mixed Models in Medicine by Helen Brown and Robin Prescott, and delegates will each receive a copy of the latest edition.
Who should attend?
The course is directed at medical statisticians who wish to understand the statistical background to mixed models to carry out analyses using SAS.
Conventionally, clinical data is analysed using fixed effects models. However, benefits can often be gained by using a mixed model. For example: in repeated measures trials full allowance can be made for the correlation occurring between the repeated observations even if data are missing; in multi-centre trials treatment standard errors are more appropriately based on between centre variation (fixed effects standard errors are based on within centre variation); in crossover trials more accurate treatment means are often achieved by combining within and between patient estimates.
Suitable procedures are readily available for fitting these models well known packages such as SAS. This has led widespread application and knowledge of mixed models becoming essential for medical statisticians. As with any statistical technique a firm understanding of the theoretical background is essential to allow its effective application and to obtain a clear interpretation of results.
Helen Brown is the Senior Statistician at The Roslin Institute, University of Edinburgh, and has a research interest in mixed models. She has over thirty years of practical experience as a statistician mainly in medicine and the biosciences.
Most of her career has been within academia but she also has experience within the pharmaceutical industry and the health service. She has co-authored three editions of the text book ‘Applied Mixed Models in Medicine’ and taught many short courses on mixed models both in Edinburgh and for external institutions.
This course will cover the statistical background to the mixed model and will emphasise their practical application to medical data with particular reference to clinical trials. All analyses will be illustrated using SAS (mainly PROC MIXED and PROC GLIMMIX) and lectures will be combined with practical sessions in order to reinforce concepts. Topics covered include:
- General concepts and underlying statistical theory
- Use of PROC MIXED
- Application in multi-centre trials
- Application in crossover trials
- Consideration of issues such as biased standard errors, significance testing and negative variance components
- Application in repeated measures trials
- Generalised linear mixed models (GLMMs) and PROC GLIMMIX
- Overview of other types of mixed models: for categorical data, highly structured data; brief introduction to the Bayesian approach and PROC MCMC
Practical sessions will focus on constructing models and interpreting results from SAS output and will not involve "hands on" computer work.
Registration will be from 9am on Day 1 and the course will end at 3pm on Day 2.
The course will be held in the Holiday Inn, Edinburgh-West, 1.5 miles from the city centre and easily accessible from the main railway station and airport. Course participants have the opportunity to stay at the Holiday Inn at a discounted rate of £72.00 per night. To book at this rate please call the Holiday Inn Events Department on 0131 311 4930 or email firstname.lastname@example.org and quote code U97. Alternatively there are several other hotels and guest houses within walking distance of the Holiday Inn.
Holiday Inn, Edinburgh-West
The Holiday Inn Edinburgh-West hotel offers you an excellent base for exploring the famous city of Edinburgh, located only 1.5 miles from Edinburgh's bustling city centre and a mere 2 miles from the world famous Edinburgh Castle.
Course Dinner Details - To Follow
Standard rate £650
Non-profit making organisations £450
Fees include lunches, dinner on the first day, unlimited tea and coffee available throughout the day, course notes and a copy of the text book "Applied Mixed Models in Medicine" (third edition) by Helen Brown and Robin Prescott.
Members of the International Society for Clinical Biostatistics (ISCB) are entitled to a £25 reduction in the course fee.
TERMS AND CONDITIONS
In the event of cancellation, the following charges will apply: if cancelled more than 30 days prior to the first day of the course, a cancellation charge of 50% of the course fee; if cancelled less than 30 days prior to the first day of the course, the cancellation charge will be 100% of the course fee. No charge will apply if an alternative delegate is substituted.
0131 651 2189 (Option 2)
0131 667 7271